DNA Probes Services

DNA probes have been developed and used well since the first construction in 1950's. As well known, the probes can work by providing a DNA strand to target the other through base pair hybridization, which as a result form a classic Watson–Crick double helix structure. Based on this, several DNA probe strategies have been developed in recent years, including fluorescence in situ hybridization (FISH), DNA molecular beacons (MBs), and toehold-based double-stranded DNA (dsDNA) probes, etc.

With a target sequence in mind, DNA probes with the length of 15-60 bps could be designed depending on different application purposes. For example, a shorter probe can be used for PCR, while longer can be used to build a biosensor by functionalizing material surfaces, such as silicon nitride, plastic, carbondiimide, etc. Multiple biochemical/biomedical applications of DNA probes have been successfully achieved by the utilization of various advanced techniques, such as some laboratory techniques including PCR, qPCR, blotting, etc. More recently, due to increasing understanding of DNA nanostructure-based nucleic acid probes, their applications have been involved in not only biosensors but bioimaging, cell assembly and capture and cancer therapy (Figure 1).

Schematic of DNA nanostructure-based nucleic acid probesFigure 1. Schematic of DNA nanostructure-based nucleic acid probes:
construction and biological applications. (Wang D X, et al. 2021)

Creative Biogene has been dedicated to providing multiple DNA probes with high-quality services and on time delivery.

  • Products include dual-labeled probes, Molecular beacons, Scorpions, etc.
  • Scales: small to large scales are available.
  • All the DNA products will be determined by using MALDI-TOF, HPLC purification, Electrospray Ionization (ESI) Mass Spec and OD by UV spectroscopy.
  • Shipments include a quality assurance document for your records.

Please check the following pages for more detailed product information.

References:

  1. Wang D X, Wang J, Wang Y X, et al. DNA nanostructure-based nucleic acid probes: construction and biological applications. Chemical Science, 2021, 12(22): 7602-7622.
  2. Vizzini P, Iacumin L, Comi G, et al. Development and application of DNA molecular probes. Journal of Bioengineering, 2017, 113-132.
* It should be noted that our service is only used for research, not for clinical use.

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