Circular oligonucleotides are covalently closed single DNA or RNA strands. Compared with their linear structures, circular oligonucleotides are more resistant to nucleases and can resist degradation by many cellular DNA and RNA decay mechanisms. Circular DNA oligonucleotides or circular RNA oligonucleotides can be chemically synthesized using a part of linear precursor as a substrate by solution and solid-phase synthesis methods and then used in the fields of diagnosis and therapy.
As a professional biotechnology company, Creative Biogene can provide you with the synthesis and modified services of certain sequence circular oligonucleotides. After removing the linear DNA from the final compound, we use PAGE to purify the synthesized circular oligonucleotide to achieve the required purity. We also use mass spectrometry to analyze the quality of the final product to ensure that you get high-quality products. In addition, our scientists will provide you with free consultation and technical support to meet your research needs in the fields of molecular biology, diagnostics and drug discovery. If you have any needs, please feel free to contact us.
Dry powder or solution delivery, according to your needs of the separate packing.
COA files, including original data and the final output excel file etc.