Antisense Oligonucleotides Synthesis

Antisense oligonucleotides (ASO) are synthetic polymers, usually 15-25 bases in length. In antisense technology, single-stranded DNA fragments are combined with mRNA to form a duplex, which prevents mRNA from being translated into protein and reduces the upstream signal transduction of protein expression. Therefore, antisense oligonucleotides can regulate gene expression in living cells and are used in the treatment of diseases for which genetic targets and their sequences have been identified.

Antisense Oligonucleotides Synthesis

As a professional biotechnology company, Creative Biogene can provide you with the modification and synthesis services of antisense oligonucleotides with a certain sequence. We use high performance liquid chromatography (HPLC) or PAGE to purify the synthesized antisense oligonucleotides to achieve the desired purity. In addition, our scientists will provide you with free consultation and technical supports to meet your research needs in the fields of molecular biology, diagnostics and drug discovery. If you have any needs, please feel free to contact us.

Our Services

Services Yield Purification Modifications Price
ASO Synthesis R & D level: μg-mg HPLC PTO, 2'-F, 2'-OME, 2'-MOE, LNA, Cholesterol, GalNAc, etc. Inquiry
Manufacturing level: g HPLC PTO, 2'-F, 2'-OME, 2'-MOE, LNA, Cholesterol, GalNAc, etc. Inquiry

Antisense oligonucleotides provided by Creative Biogene is carefully monitored during the synthesis process and controlled according to strict quality control standards. The final product is identified by a variety of techniques, its purity is analyzed by HPLC. After the experiment is completed, in addition to providing you with customized products, we also provide you with all the original data, normalized data and the final output as an excel file.


Dry powder delivery, according to your needs of the separate packing.
COA files.

Our Advantages

  • Personalized customization: We can provide a variety of modification types and flexible synthesis specifications.
  • Strict quality control: The quality of our products is strictly controlled, and all nucleic acid synthesis products are analyzed by mass spectrometry.
  • Quality analysis: HPLC and LC-Mass analysis and QC methods and documents can be provided according to your needs.
  • Professional support: Our team of nucleic acid synthesis experts has many years of experience and provides professional consultation and technical support.
  • Fast delivery: Flexible project arrangement shortens delivery time.
* It should be noted that our service is only used for research, not for clinical use.
Online Inquiry